Ahead of Liverpool's trip to Manchester United, TEAMtalk has scoured YouTube for some classic moments in previous Old Trafford meetings.
1980: Dalglish embarrassed after Hansen springs world's worst offside trap:
With both clubs going for the title, Kenny Dalglish had already put Liverpool ahead at Old Trafford. But, later in the half, the future Reds manager combined with Alan Hansen to make a complete mess of a golden opportunity presented to them by the highest defensive line in the history of association football.
It cost Liverpool on the day as goals from Mickey Thomas and Jimmy Greenhoff gave United a 2-1 victory. But Liverpool had the last laugh as they went on to win their 12th First Division title but a margin of two points.
1989: Fergie's Fledglings fightback on New Year's Day:
Champions Liverpool were putting together a solid defence of their title the previous season when they arrived at Old Trafford on the first day of 1989.
Alex Ferguson was still struggling to inject any consistency into his United side at the time and only sixth place was on offer for the Red Devils if they could turn over the First Division champions.
John Barnes took great delight in regularly hurting United around the turn of the decade, and it was the wing wizard who opened the scoring with 20 minutes remaining.
Barnes also scored twice at Old Trafford the following season when Liverpool won 2-1 in a match more famous for Ronnie Whelan's stunning own-goal - a delightful chip from outside his own box that floated over Bruce Grobbelaar, a video of which, bizarrely, cannot be found anywhere. Whelan must have a friend in a very high place somewhere...
But back to 1989. Youngsters Lee Sharpe and Russell Beardsmore led United's recovery from the flanks. Brian McClair volleyed United back into the game, before Mark Hughes and Beardsmore sealed a much-enjoyed victory.
The defeat hurt Liverpool, as they went on to lose the title with almost the last kick of the season to Arsenal.
1991: Barnes' brilliance sets up Speedie reply after Hysen's brain-freeze:
FA Cup holders United were still smarting from their 4-0 demolition at Anfield earlier in the 1990/91 season, during which Peter Beardsley helped himself to a hat-trick. All eyes, though, in February were on another Liverpool forward - David Speedie, who was making his debut for the club having just become Dalglish's final signing before the manager resigned later that month.
Speedie, thanks largely to Barnes' genius, notched on his first appearance, but only after Glenn Hysen bizarrely thought his own penalty box was a suitable arena to audition for the Sweden volleyball team.
2006: Gary Neville loses it after last-minute winner:
Liverpool had dominated this January 2006 clash but were left to rue Djibril Cisse's open-goal miss when Rio Ferdinand climbed highest to head Ryan Giggs' free-kick past Pepe Reina in the final minute.
This was clearly too much for Neville, who had stayed back at the the free-kick to guard against a counter attack.
Neville's display cost him £5000 and a warning about his future conduct from the FA. This pleased the United captain rather less than Ferdinand's winner. Reacting to his punishment, he sarcastically remarked: "Being a robot, devoid of passion and spirit, is obviously the way forward for the modern-day footballer."
2009: Rafa's resilient Reds recover to fire four past stunned United:
As both sides prepared for the title run-in as contenders, few foresaw what took place on a remarkable Saturday lunchtime in March 2009.
Cristiano Ronaldo opened the scoring from the penalty spot, but that was as good as it got for the champions. Liverpool led by half-time thanks to Fernando Torres and the camera-kissing Steven Gerrard, before two unlikely scorers, Fabio Aurelio and Andrea Dossena completed the rout.
Nemanja Vidic endured a torrid time against the Torres of old, and his afternoon came to an early conclusion with a red card - his second of the season against Liverpool.
United took their revenge, however, by regaining the Premier League title to draw level with Liverpool's haul of 18 championships.
What memories do you have of previous Old Trafford meetings between the two rivals? Use the Story Comment facility to reminisce and post your own YouTube links.