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Switzerland shocked Greece, Israel were held by Latvia and Luxembourg drew with Moldova.
Greece had won their first three matches without conceding a goal, while Switzerland had struggled in the early part of their campaign.
The form book was turned upside down though as Switzerland ran out 2-1 winners in Athens.
Alexander Frei's penalty three minutes before half-time set Switzerland on their way, but Angelos Charisteas equalised for Greece in the 68th minute.
Switzerland were not to be denied and secured all three points courtesy of Blaise N'Kufo 13 minutes from time.
Israel could only pick up a late point on their travels as Latvia scored one minute from time to rescue a 1-1 draw in Riga.
Yossi Benayoun netted against Luxembourg at the weekend and the Liverpool midfielder found the target again to put Israel in front five minutes into the second half.
However, their World Cup hopes suffered a blow with just one minute remaining as Vladimirs Kolesnichenko levelled for Latvia.
There was a point apiece for Luxembourg and Moldova in the day's final game as the two minnows played out a goalless draw.

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