Swindon defender Troy Archibald-Henville could be out of action for up to six months with knee cartilage damage.
The 24-year-old, signed for £200,000 from Exeter in the summer, will undergo exploratory surgery to assess how bad the damage is and how long the centre-back will be sidelined for.
"He's going to have surgery probably on Monday to check exactly what problem he's got," Paolo Di Canio told the Swindon Advertiser.
"Even if it takes six months at the worst, you're going to have the best implant, the best situation and he knows in six months he can come back and he is young, not 35.
"He can have the rest of his career with more chances to play and train hard as an athlete."