Team news ahead of Tuesday evening's CFR Cluj-Napoca's Champions League clash with Manchester United at the Dr Constantin Radulescu Stadium.
Sir Alex Ferguson has left experienced midfield trio Paul Scholes, Ryan Giggs and Michael Carrick out.
Carrick did not train at Carrington and was also absent when United left Manchester at lunchtime.
But rather than being rested, Ferguson confirmed the England man was not well enough to be considered.
"Michael did not report today. He is in bed with a virus," said Ferguson.
The United boss also confirmed Giggs left training this morning after also feeling unwell, while Scholes was not considered due to the exertion of completing the full 90 minutes in Saturday's 3-2 home defeat by Tottenham.
"Ryan had a bit of a virus this morning," said Ferguson.
"He was feeling a bit rough so we sent him home.
"Paul Scholes played ever so well on Saturday but he is 37 now and we couldn't expect him to play three days later at his age."
The Red Devils, who suffered a shock 3-2 home defeat the hands of Tottenham in the Premier League on Saturday evening, have named several youngsters in their 21-man travelling party.
Carrick's goal ensured Ferguson's side beat Galatasaray 1-0 in their opening Group H encounter and they will be keen to build on that success in Romania on Tuesday evening, with their opponents currently top of the standings after a 2-0 success away to Braga.
There was some good news for Ferguson with Jonny Evans available despite taking a knock in the closing stages against Spurs, with Nemanja Vidic, Chris Smalling and Phil Jones all remaining on the sidelines through injury.
Evans and Rio Ferdinand are expected to be paired in the centre of defence, while Michael Keane and Scott Wootton have been included as cover.
Antonio Valencia (ankle) and Ashley Young (knee) will not feature, meaning Darren Fletcher, Jesse Lingard, Nick Powell and Ryan Tunnicliffe are among Ferguson's midfield options.
Man United (from): De Gea, Lindegaard; Buttner, Evans, Evra, Ferdinand, M. Keane, Rafael, Wootton; Anderson, Cleverley, Fletcher, Lingard, Nani, Powell, Tunnicliffe; Hernandez, Kagawa, Rooney, van Persie, Welbeck.