Sir Alex Ferguson takes charge of his final Manchester United home game when Swansea City visit Old Trafford on Sunday.
Whether to recall Wayne Rooney is likely to be Ferguson's biggest selection dilemma following reports that the striker has asked to leave United in the summer.
Rooney started on the bench against Chelsea last weekend, but will hope for a recall, and there could also be a place for Paul Scholes following his spot among the substitutes a week ago after three months out through injury.
Ferguson stalwarts Rio Ferdinand and Ryan Giggs may also start, and David de Gea could be restored in goal after Anders Lindegaard was given a chance in the 1-0 defeat by Chelsea.
Angel Rangel and Michel Vorm will miss Swansea's trip to face the Premier League title winners.
Right-back Rangel has a calf injury, while Vorm is still recovering from the concussion he suffered in the midweek win at Wigan.
But Michu could be set for a surprise return from a hamstring injury, just a week after manager Michael Laudrup had said he would miss the remainder of the season. Centre-half Chico Flores is also in contention.
If Michu is not involved, then Itay Schechter will hope to keep his place after scoring his first Premier League goal against Wigan.