Southampton's new manager Mauricio Pochettino must decide whether to bring top scorer Rickie Lambert back into the starting line-up for the clash with Everton.
Lambert came off the bench to head his 10th Premier League goal of the season in Wednesday's 2-2 draw at Chelsea.
Pochettino, who is expected to face fan protests over the sacking of Nigel Adkins during his first game in charge, will monitor the fitness of Adam Lallana, who has returned to light training after a knee injury.
Kevin Mirallas is not expected to be risked for Everton after virtually two months out with a hamstring injury.
The Belgian is reported to be back in training but, after attempting to come back last month and breaking down again, manager David Moyes will not want to rush him.
Defender Johnny Heitinga could return after missing the last two games with a knock but full-back Tony Hibbert (calf) and midfielder Darron Gibson (thigh) remain on the sidelines.