Xisco was among a 20-strong Newcastle party which arrived in Belgium on Wednesday ahead of Thursday night's Europa League clash with Club Brugge.
The Spaniard, who scored a hat-trick for the club's Under-21s side against Stoke last month, was on the plane along with Fabricio Coloccini and Cheick Tiote, who are both likely to feature as they are suspended for Sunday's Premier League fixture against West Ham.
Yohan Cabaye, who left the field at Liverpool at the weekend with a tight hamstring, has also been included, but defenders James Perch (thigh) and Danny Simpson (shoulder) and striker Demba Ba (shin) stayed behind along with senior men Steve Harper and Hatem Ben Arfa.
Club Brugge have one long-term absentee, with Victor Vasquez not expected back from his collarbone injury until the end of the year.
Caretaker boss Philippe Clement has just 18 fit first-team players at his disposal, with Jesper Jorgensen and Vadis Odjidja the only available midfielders.
Macedonian forward Ivan Trickovski and Israeli international Lior Refaelov failed fitness tests this week.