West Brom goalkeeper Boaz Myhill will again provide cover for Ben Foster, who is recovering from groin surgery.
Albion are sweating over the fitness of defender Gareth McAuley, who suffered a hamstring injury playing for Northern Ireland against Azerbaijan, with Gabriel Tamas on stand-by to deputise.
But they are more hopeful midfielder Youssouf Mulumbu will be fit after a hamstring injury led to him withdrawing from midweek action with Congo. On-loan Chelsea striker Romelu Lukaku is ineligible to face his parent club.
Chelsea will once again be without the services of club captain John Terry after he picked up a knee injury during a meeting with Liverpool last weekend.
The centre-half made his return to Premier League action after serving a four-match ban in a 1-1 draw with the Reds, but is now facing up to another spell on the sidelines.
Ashley Cole, who has been nursing a hamstring problem, and Frank Lampard, who has a calf complaint, remain doubtful, while Di Matteo will be hoping that a midweek trip to the USA has not taken too much out of Brazilian duo Oscar and David Luiz.