Mousa Dembele is unlikely to make Tottenham's side for Thursday's Europa League clash at Lazio (kick-off 6pm).
The Belgian playmaker has been carrying a hip injury and although he has travelled with the squad to Rome, is not expected to prove his fitness in time.
Scott Parker (Achilles), Benoit Assou-Ekotto and Younes Kaboul (both knee) are all sidelined, and England defender Steven Caulker is also doubtful with a knee problem.
Goalkeeper Brad Friedel has remained in London with the injured Yago Falque - meaning a rare start for France stopper Hugo Lloris, who has found chances hard to come by since his 10m-euro move from Lyon in the summer.
Lazio, meanwhile, can call on the likes of veteran forward Miroslav Klose - joint second in the all-time World Cup goalscorers list.
Spurs currently sit in second place in Group J behind their table-topping hosts with two games still to play.