Stoke manager Tony Pulis will be forced into a defensive reshuffle for Saturday's Premier League visit of Southampton to the Britannia Stadium.
Captain Ryan Shawcross and right-back Geoff Cameron both serve one-match bans for accruing five bookings this season.
It means Matthew Upson is likely to replace Shawcross in the centre of the back four, with Ryan Shotton coming in for Cameron.
Adam Lallana will be on the sidelines once again for Southampton.
The Saints captain picked up a knee problem against Reading on December 8 and has not featured since.
Manager Nigel Adkins revealed one or two unnamed players picked up knocks in the 1-1 draw with Fulham on Boxing Day, but expects them to be available at the Britannia Stadium.