Wayne Rooney has been ruled out of Sunday's Premier League clash with Liverpool as he continues his recovery from a knee problem.
It means Javier Hernandez is set to partner Robin van Persie in attack for Sir Alex Ferguson's side.
United are boosted by the return of Nani and Anderson from injury with the pair likely to be on the bench.
Nani has been sidelined since the beginning of November with a hamstring injury while Anderson has been missing since he also reported a hamstring problem in early December.
Liverpool boss Brendan Rodgers has no fresh injury worries to contend with as he must decide whether or not to hand new signing Daniel Sturridge his Premier League debut.
Sturridge scored on his debut in last weekend's FA Cup win over Mansfield, but is still struggling for match fitness after his move from Chelsea.
Jose Enrique remains sidelined for Liverpool with a hamstring strain, meaning Glen Johnson is set to deputise at left-back with Andre Wisdom starting at right-back.