Liam Bridcutt returns to the Brighton squad for the visit of Wolves but Bruno and Inigo Calderon are out.
Midfielder Bridcutt was rested for last weekend's 2-1 win at Leeds and boss Gus Poyet confirmed he is set to play.
But Bruno suffered a calf injury at Elland Road while fellow full-back Calderon was sent off and serves a one-match ban.
Centre-half Adam El-Abd or midfielder Dani Lopez could therefore be asked to fill in at right-back.
Left-back Wayne Bridge was also rested at Leeds and his fitness will be assessed ahead of the match.
Strikers Craig Mackail-Smith (Achilles) and Will Hoskins (knee) are still out but Poyet says he will not make major changes despite already being assured of fourth place and a play-off spot.
Bakary Sako is touch and go for Wolves' final-day trip to Brighton as the Black Country club go all out to try and salvage their Championship status.
The influential French winger rushed back from a hamstring lay-off for last weekend's crucial clash at home to Burnley but, despite coming off the bench just before the hour mark, could not inspire a turnaround as Wanderers went down 2-1.
Sako suffered a slight reaction from his 30-minute outing and is now a doubt for the encounter at the Amex Stadium.
But Wolves are boosted by the return of midfielder Jamie O'Hara after he completed his three-match suspension.
Long-term absentees David Davis (ankle), Carl Ikeme (broken hand), Sylvan Ebanks-Blake (broken leg), Dave Edwards (metatarsal) and Razak Boukari (calf) remain unavailable.
Manager Dean Saunders must lead his side to victory over in-form play-off contenders Brighton and hope both Peterborough and Barnsley lose, while also turning around a four-goal swing, to stand a chance of survival.