Robin van Persie is a doubt for Manchester United's game against Southampton at Old Trafford on Saturday after the Dutch striker picked up a calf injury on international duty.
Rio Ferdinand is expected to be drafted back into the side after sitting out their last two fixtures with fatigue and a slight groin complaint.
Tom Cleverley was forced to miss England duty due to a calf problem and remains a doubt heading into the weekend, while Darren Fletcher is a long-term absentee with a chronic bowel condition.
Manchester United boss David Moyes may be tempted to hand a first Old Trafford start to man of the moment Adnan Januzaj, with the youngster having bagged a match-winning brace in United's last outing at Sunderland.
Artur Boruc and Luke Shaw will both come into contention for Southampton on Saturday.
Saints boss Mauricio Pochettino expects Boruc to start again in goal, despite the Poland team physio claiming he suffered a hamstring injury during the international break.
Shaw was unable to link up with the England U21s due to illness but is okay for domestic duty, while Gaston Ramirez will be assessed after arriving back from international duty with Uruguay late on Thursday.