Hull will be without Paul McShane for the visit of Liverpool after he picked up a hamstring injury in last weekend's defeat to Crystal Palace.
It means Steve Bruce will be forced into a defensive reshuffle at the heart of his backline.
James Chester is still working his way back to fitness and it means Abdoulaye Faye and Alex Bruce are battling it out to replace McShane and partner Curtis Davies in central defence.
Sone Aluko remains sidelined with an Achilles injury, while Stephen Quinn also faces a spell out of action with a hamstring complaint.
Liverpool boss Brendan Rodgers is unlikely to have striker Daniel Sturridge available after he suffered an ankle injury in training on Friday.
Sturridge didn't start the 3-3 draw with Everton, but came off the bench to net the equaliser. He had been expected to start before getting hurt at Melwood on Friday.
Jose Enrique has been ruled out until February and Jon Flanagan will be hoping to keep his spot at left-back after impressing in the Merseyside derby.
Sebastian Coates remains a long-term absentee otherwise Rodgers has no other injury concerns to deal with.