Clint Dempsey and Lamar Neagle scored second half goals to give the Seattle Sounders a 2-2 draw with the LA Galaxy.
Chris Pontius and Eddie Johnson were both on target for D.C. United as they beat the Chicago Fire 2-1.
Bradley Wright-Phillips scored his 25th MLS goal of the season as New York Red Bulls claimed a 3-1 win over Toronto FC.
A controversial Kekuta Manneh goal earned Vancouver Whitecaps a hard-fought 1-0 win against Seattle Sounders.
Jermain Defoe is committed to Toronto, but the franchise's boss has refused to rule out the prospect of a January move.