Arsenal's Santi Cazorla, Chelsea's Fernando Torres, Tottenham's Aaron Lennon and Aston Villa's Christian Benteke could return this weekend.
Newcastle United v Liverpool, 12.45pm
Newcastle are without Fabricio Coloccini and Jonas Gutierrez, while Liverpool welcome back Glen Johnson, Joe Allen, Aly Cissokho and Lucas Leiva to their squad. Read full Newcastle v Liverpool preview.
Key stat: Liverpool have scored 10 and conceded only one goal in the first half of Premier League games this season, but in the second half they have netted just once and conceded four.
Arsenal v Norwich City
Mesut Ozil, Santi Cazorla and Bacary Sagna have all been passed fit for Arsenal, while Norwich have doubts over Anthony Pilkington and a number of other unnamed players. Read full Arsenal v Norwich preview.
Key stat: Arsenal have collected more points (56) and more wins (17) in the Premier League in 2013 than any other side.
Chelsea v Cardiff City
Chelsea are likely to be without Ashley Cole but have Fernando Torres available again, while summer signing Andreas Cornelius remains the only injury victim for Cardiff. Read full Chelsea v Cardiff preview.
Key stat: Chelsea have won 10 and drawn one of their last 11 Premier League games at Stamford Bridge.
Everton v Hull City
Everton are without Darron Gibson, who faces several months on the sidelines with a knee injury, Steven Pienaar and Antolin Alcaraz, while Hull are hoping to welcome back Robbie Brady after his hernia operation. Read full Everton v Hull preview.
Key stat: Romelu Lukaku has scored four goals and made one assist in just 217 minutes of action since moving to Goodison Park.
Manchester United v Southampton
United boss David Moyes is sweating over Robin van Persie, but is expected to recall Rio Ferdinand and may be tempted to start Adnan Januzaj. Southampton have Artur Boruc and Luke Shaw available again. Read full Manchester United v Southampton preview.
Key stat: Excluding penalties, Robin van Persie has failed to score in 14 of his last 18 Premier League games, including the last five in a row.
Stoke City v West Bromwich Albion
Jon Walters is fit to make his 97th consecutive Premier League appearance for Stoke, while West Brom have a similarly strong squad available with only Ben Foster and Scott Sinclair unavailable. Read full Stoke v West Brom preview.
Key stat: No side has lost more Premier League games in 2013 than Stoke City (15).
Swansea City v Sunderland
Swansea remain without Ashley Williams and have a major doubt over Ben Davies, while Sunderland should be able to welcome back Steven Fletcher. Read full Swansea v Sunderland preview.
Key stat: Swansea have currently gone eight successive home games without a win in the Premier League; the longest current run.
West Ham United v Manchester City, 5.30pm
West Ham are without James Collins, Alou Diarra, Andy Carroll and Carlton Cole, who is not yet fit enough to play after rejoining the club, while Manchester City are without defensive duo Vincent Kompany and Martin Demichelis. Read full West Ham v Manchester City preview.
Key stat: Yaya Touré, who has either scored or assisted in five of his seven league appearances this season, has scored three goals in four appearances against the Hammers.
Aston Villa v Tottenham Hotspur, Sunday 4pm
Christian Benteke could return for Villa, while Aaron Lennon is expected to return to the Spurs squad but is unlikely to play from the start with Andros Townsend in such good form. Read full Aston Villa v Tottenham preview.
Key stat: Aston Villa have not kept a clean sheet in any of their last 14 Premier League home games, losing nine in this run (W4 D1).