Manchester United's woes, Chelsea's hoodoo over Spurs and Arsenal's fine FA Cup record feature in our look at the stats ahead of the weekend.
TEAMtalk takes a look at all the key Opta stats ahead of the weekend's Premier League and FA Cup action.
With Liverpool enjoying a weekend off and both Arsenal and Manchester City in FA Cup action, Chelsea could move seven points clear at the top of the Premier League table if they beat Tottenham on Saturday evening - and their recent record against their London rivals will provide them with optimism.
Manchester United, meanwhile, will hope to make the close the gap on the teams above them when they travel to West Brom in the early game on Saturday, while the games involving Cardiff and Fulham, Crystal Palace and Southampton, and Norwich and Stoke could be crucial in the battle to avoid relegation.
West Bromwich Albion v Manchester United
West Brom have conceded the highest proportion of first-half goals in the Premier League this season (54%).
Wayne Rooney has scored six goals in his last five Premier League starts against West Brom.
This fixture ended 5-5 last season in the highest scoring draw in Premier League history and was also Sir Alex Ferguson's final game in charge as Manchester United boss.
The Baggies have drawn 1-1 at home to three of the top four this season and narrowly lost 3-2 to Manchester City.
Prior to this season's defeat at Old Trafford by the Baggies, United had previously won 11 and lost none of the 14 Premier League matches with West Brom.
West Brom have scored own goals in three of the last five Premier League meetings with Manchester United.
Robin van Persie has scored four goals in his last six Premier League appearances against West Bromwich Albion.
The Red Devils' 45 point tally after 27 games of this Premier League season is five points worse than their previous lowest in 1992-93 (50).
David Moyes' side have won three and lost three of their last eight Premier League outings (D2).
Manchester United are one of four teams yet to concede a penalty in the Premier League along with Manchester City, Cardiff and Chelsea.
Cardiff City v Fulham
Cardiff have the best disciplinary record in the top flight, picking up just 34 yellow cards and no reds.
Fulham have gone 13 Premier League away matches without a clean sheet.
Four of the last five matches between Cardiff and Fulham have ended with a 2-1 scoreline.
Fulham have won one and lost seven of their last 10 Premier League away games (D2).
Cardiff have failed to score in four of their last six Premier League home games.
Only Fulham (181) have allowed their opponents more shots on target against them than Cardiff City this season (165) in the Premier League.
Cardiff have conceded more headed goals than any other team in the top flight (10).
The Welsh side have scored 74% of their goals in the second half of games, the highest percentage in the top tier.
Fulham have conceded 68% of their goals in the second half of this season; the highest proportion in the Premier League.
Cardiff are the only team in the Premier League that are yet to give away or win a penalty kick this season.
Crystal Palace v Southampton
Crystal Palace have scored 21% of their goals in the opening 15 minutes of matches, the highest proportion in the Premier League.
Rickie Lambert has scored three goals in his last two league appearances against Palace.
The last four matches in all competitions between Palace and Southampton have ended as 2-0 wins.
Crystal Palace have failed to score in their last four league games against Southampton.
Crystal Palace have won five and lost two of their last nine Premier League home matches (D2).
Southampton have won three and lost just two of their last seven Premier League away games (D2).
The Eagles have conceded the joint-most penalties in the Premier League (six along with Everton).
Southampton have only won four of their last 17 Premier League games (W4 D5 L8).
Crystal Palace have been very susceptible to shipping goals after the half-time break, with 11 goals conceded in the 46-60 minute period of games, accounting for 30% of their total goals conceded - both league highs.
Crystal Palace have scored 47% (9/19) of their goals from set pieces, the highest proportion in the top flight.
Norwich City v Stoke City
Norwich City have kept four clean sheets in a row in the Premier League at Carrow Road.
Stoke City have lost nine and won none of their last 12 Premier League away matches.
There have been just six goals in the five Premier League meetings between Stoke and Norwich and the last four have all ended with a 1-0 scoreline.
The average of 1.20 goals per game makes this the third lowest scoring fixture in Premier League history (minimum five meetings) after Man City v Sheffield United (1.00) and Bolton v Southampton (1.17).
Chris Hughton's side have scored just five goals in their last eight Premier League home games and just two in the last five.
Norwich have scored with just 8.1% of their shots, the lowest proportion in the Premier League.
Stoke have the worst disciplinary record in the top flight having committed the most fouls (373) and picked up the most cards (61 yellows and three reds).
Stoke have scored just two headed goals this season, the joint-fewest in the Premier League along with West Ham.
Ricky van Wolfswinkel scored with his first shot at goal in the Premier League on the opening day of the season but has attempted just three shots on target (scoring none) in 17 PL apps since.
No team has picked up fewer points away from home than Stoke City in the Premier League this season (six, along with Cardiff City).
Chelsea v Tottenham Hotspur
Chelsea have picked up the most points on home soil in the Premier League (38) this season.
No team have earned more points away from home in the Premier League than Tottenham (29).
Emmanuel Adebayor has scored seven goals in his last six Premier League appearances away from home.
Adebayor has scored in three of his last four Premier League starts against Chelsea.
Chelsea have lost none of the last seven Premier League meetings against Spurs, winning two and drawing five.
In those seven games, Spurs have been ahead in five matches, but gone on to win none.
Chelsea have lost none of their last 26 home games against Tottenham in all competitions, winning 16.
The last player to score a winning goal for Tottenham at Stamford Bridge was Gary Lineker in February 1990.
Gylfi Sigurdsson could make his 50th Premier League appearance for Spurs in this match - the Icelandic international has scored in his last two PL appearances against Chelsea.
In 74 Premier League home games under Jose Mourinho, Chelsea have won 58 and lost none.
FA Cup quarter-finals
Arsenal v Everton
Arsenal and Everton have only met three times before in the FA Cup with the last time being in 1981. The Toffees have won twice (1910 & 1981) and Arsenal once (1928).
Everton have won none of their last 19 away games against Arsenal in all competitions (W0 D4 L15), but have drawn the last two visits.
Robert Martinez was coach of the Wigan Athletic side that won the FA Cup last season. His side's victory came three days before being relegated from the Premier League with a defeat at the Emirates Stadium.
Arsenal are unbeaten at the Emirates Stadium in their last 13 matches in domestic competition, winning 10 and drawing three.
The Gunners have conceded just three goals in their last 13 domestic games at the Emirates, but Everton were one of those scorers in a 1-1 draw in the Premier League in December 2013.
Mesut Ӧzil's last goal for Arsenal came in the 1-1 draw against Everton back on December 8, 2013.
Arsenal have progressed in 10 of their last 11 quarter finals, the exception being their last one in 2011 when they lost 2-0 to Manchester United.
Arsenal have only lost two home FA Cup ties under Arsene Wenger in 39 matches (W27 D10 L2): against Leeds in Round 4 in 1997 and versus Blackburn last season in Round 5.
Lukas Podolski has scored four goals in four FA Cup appearances for the Gunners.
Everton have only won one of their last 10 FA Cup matches away from home against a fellow top-flight team (W1 D4 L5).
Steven Naismith has scored three goals in his last two FA Cup appearances.
The last team to beat Everton in an FA Cup match were Wigan Athletic, who were managed by their current coach Robert Martinez, last season in the quarter-final.
Sheffield United v Charlton Athletic
Sheffield United and Charlton Athletic have been drawn together three times before in the FA Cup with the Blades winning all three times, once after a replay (P4 W3 D1 L0).
Sheffield United have already knocked out three teams from higher divisions: Aston Villa (Round 3) and Fulham (Round 4) from the Premier League and Nottingham Forest (Round 5) from the Championship.
Chris Porter of Sheffield United has scored four goals in six FA Cup appearances this season.
Porter has netted just five goals in his 21 appearances this season in League One.
Prior to this season, the Blades had won none of their previous eight FA Cup matches against teams from a higher division (W0 D2 L6).
Charlton have lost none of their last seven FA Cup matches against teams from a lower division (W4 D3 L0).
Simon Church has scored the winning goal in each of the last two FA Cup ties the Addicks have won.
The last time these two sides met was in League One in 2011-12 when the Londoners won both home and away games without conceding.
In 2014, Charlton have saved their good form for the FA Cup with a record of P4 W3 D1 L0, while in the Championship they have struggled (P7 W1 D1 L5).
All three of Charlton's FA Cup victories this season have come away from home.
Hull City v Sunderland
There have been three FA Cup meetings between Hull and Sunderland, the last of which came in 1976 when the Wearsiders won 1-0 at Roker Park.
Sunderland also beat Hull in their first ever two meetings in any competition in FA Cup matches in 1920 (6-2 home win) and 1933 (2-0 away win).
Sunderland striker Jozy Altidore played 30 times for Hull City in 2009-10, scoring just two goals. He made one FA Cup appearance as a substitute in a 4-1 defeat by Wigan.
Altidore has played 32 times for Sunderland and also scored just two goals in that time.
Sunderland have not won four FA Cup matches in a row since they won the final in 1973.
The Black Cats have won just two of their last 31 away FA Cup games against a team from the top division (W2 D11 L18).
One month ago, Hull completed the league double over Sunderland with a 2-0 win at the Stadium of Light after winning 1-0 at the KC Stadium earlier in the season.
Nikica Jelavic is cup tied after already scoring two goals in one game against QPR in this season's third round for Everton.
Shane Long is also cup tied, having already played for West Brom in the competition this season, which is a shame has he has scored five goals in his last six FA Cup starts.
Hull City have kept just two clean sheets in their last 14 FA Cup matches.
Manchester City v Wigan Athletic
Manchester City played Wigan in last season's FA Cup final with the Latics running out 1-0 winners.
City have already gained a measure of revenge with a 5-0 win at the Etihad Stadium in this season's Capital One Cup back in September en route to winning the trophy.
All three of the FA Cup meetings between Man City and Wigan have ended with a 1-0 scoreline (1971, 2006 and 2013).
City have won nine and lost just one of the last 11 meetings with Wigan in all competitions.
Sergio Aguero has scored eight goals in seven FA Cup appearances for Man City.
Alvaro Negredo has netted three goals in two FA Cup starts this season.
Wigan have failed to score in their last seven visits to the Etihad Stadium in all competitions.
Nine of the 14 matches where Wigan have played away at Manchester City in all competitions have ended with a 1-0 scoreline (seven 1-0 wins for City, two 1-0 wins for Wigan).
Ben Watson has scored in three of his last four FA Cup appearances including the winner against Manchester City in last season's final.
Callum McManaman has played in 10 FA Cup ties away from the DW Stadium (including Wembley) and scored five goals.
Wigan have won their last five matches in all competitions and four of those have been away from home.