Porto won their third consecutive Liga title and completed an unbeaten season in the process after beating Pacos Ferreira 2-0.
AC Milan secured a 2-1 win at Siena to book their place in next season's Champions League at the expense of Fiorentina.
Barcelona marked the occasion of their Primera Division trophy presentation with a 2-1 home win over Real Valladolid.
Napoli coach Walter Mazzarri has confirmed he will be leaving his position after leading the club to second place.
Lyon snatched a 1-1 Ligue 1 draw at Nice on Sunday to keep themselves in pole position for the final Champions League spot.