Bundesliga leaders Bayern Munich head to Nurnberg on Saturday, Bayer Leverkusen host Schalke while Klaus Allofs begins life at Wolfsburg.
It is the beginning of a new era for the Wolves this weekend and the end of a long one for Werder Bremen after Allofs swapped one green shirt for another.
The man who had worked hand in hand with Thomas Schaaf for the past 13 years decided on Wednesday that it was time for a change, leaving Bremen to become the new director of sport at Wolfsburg, filling a position left vacant following Felix Magath's resignation last month.
"I would like to thank Werder Bremen for the past 13 years," said Allofs. "I think it is understandable that after such a long, beautiful time, it is not so easy to leave it behind.
"That is why I am so grateful that we were able to part on friendly terms. Personally, I am now very happy to be here."
Allofs left a club he helped guide to a league and cup double in 2004, as well as the final of the UEFA Cup in 2009, to join one which has struggled since winning the Bundesliga three years ago.
Those struggles have continued this season too and the Wolves are currently third from the bottom of the table going into this weekend's 12th round of Bundesliga matches.
"I am absolutely convinced that Wolfsburg have excellent conditions to take some steps forwards in future," added Allofs.
"I am looking forward to this task because we can still take Wolfsburg a long way.
"We have a team which has undoubtedly a lot of potential and, in my eyes, does not belong in the bottom half of the table."
They say that the table does not lie, though, and for Allofs' words to bear any kind of resemblance with reality, they need to pick up three points in Hoffenheim on Sunday to take the first step in the right direction.
A win there could even take the Wolves level on points with Bremen, who host Fortuna Dusseldorf without Allofs on the bench for the first time in 13 years in Sunday's other fixture.
Elsewhere this weekend, there is a Bavarian derby in Nurnberg, where the struggling hosts look to become only the second side all season to take anything off Bayern Munich.
Bayern's nearest challengers Schalke are in action at Bayer Leverkusen on Saturday evening, by which time both clubs will know how much closer, if at all, to Bayern a win would take them.
Defending champions Borussia Dortmund welcome Greuther Furth to the Westfalenstadion, Europa League participants Borussia Monchengladbach and Stuttgart meet at the Borussia Park Stadion and Hannover host Freiburg.
Finally, Thomas Tuchel takes his Mainz side to Hamburg and Eintracht Frankfurt are at home to bottom-placed Augsburg.