First-team opportunities for the 27-year-old forward appear limited at the Nou Camp where Lionel Messi, Neymar and Luis Suarez led the Catalan giants to the Champions League and La Liga titles last season.
Pedro has been linked with a move to Old Trafford following the departures of Robin van Persie and Radamel Falcao in recent weeks, while Chelsea may also be interested depending on outgoings.
And Busquets said at a press conference in San Francisco: “I have spoken with Pedro.
“I think that as a team-mate and friend, I would like him to stay for a long time but I understand that he has doubts.
“He wants to play but there is a lot of competition. In our team we have the best players and it’s very difficult.
“I hope he stays but the decision is his.”
Barca boss Luis Enrique added: “Pedro? If he wants to go, a club will have to meet his release clause.
“I have talked with Pedro to discuss his situation. I have told him how I think about it and he told me how he feels about it, but I obviously won’t reveal the exact content of the conversation we had.”
Pedro joined Barcelona’s youth team as a 17-year-old and has won the La Liga five times and the Champions League on three occasions.