Chelsea were beaten 2-0 by Rapid Vienna in Antonio Conte’s first match in charge of the Blues.
A strong side captained by John Terry and including Branislav Ivanovic, Nemanja Matic, Willian, Ruben Loftus-Cheek and Diego Costa fell behind to Brazilian teenager Joelinton’s eighth-minute goal.
Tomi Correa added a second with eight minutes remaining while, for the Blues, Costa squandered a good chance and academy graduate Ola Aina hit a post.
Stoke’s opening pre-season game ended in a 3-0 defeat against Championship new boys Burton Albion.
Chris O’Grady scored twice in the second half and Lucas Akins completed the scoring at the Pirelli Stadium.
However, City boss Mark Hughes will have been heartened by the return of goalkeeper Jack Butland and defenders Glen Johnson and Marc Wilson after long-term injury lay-offs.
Saido Berahino shrugged off the latest speculation about his future with two goals as West Brom beat Kidderminster 2-1.
The striker, who is once again being linked with a move away from The Hawthorns, scored in each half for the Baggies, who also gave a run-out to new signing Matt Phillips.
Rickie Lambert and youngster Andre Wright earned another Albion XI a 2-1 win at Stafford Rangers.
Stewart Downing and Alex Pattison scored in Middlesbrough’s 2-0 win over Doncaster.