Manchester City have won their last four FA Cup games against Chelsea but are expected to name a weakened team at Stamford Bridge on Sunday.
Chelsea captain John Terry will miss out again with the hamstring injury picked up against Newcastle United, but Guus Hiddink hopes the 35-year-old will be fit to face Southampton in the Premier League next weekend.
Oscar could start after returning from a calf injury in the midweek Champions League defeat to Paris Saint-Germain, while Nemanja Matic is available having missed that game through suspension.
Alexandre Pato is still short of match fitness, however, while Kurt Zouma (knee) and Radamel Falcao (thigh) are long-term absentees.
Manuel Pellegrini, meanwhile, is expected to field an inexperienced side ahead of a Champions League tie at Dynamo Kiev on Wednesday and the Capital One Cup final against Liverpool next weekend.
City are without Bacary Sagna, Jesus Navas, Kevin De Bruyne, Samir Nasri, Fabian Delph, Eliaquim Mangala and Wilfried Bony anyway, with Pellegrini revealing he only has 13 senior players available to pick from.
Kick-off at Stamford Bridge on Sunday is at 4pm.
Chelsea have won 24 and lost just of one of their last 29 FA Cup matches played at Stamford Bridge (excluding penalties). They were knocked out on penalties at home to Everton in 2011 during this run.
The Blues have kept five clean sheets in their last six FA Cup matches played at Stamford Bridge.
Guus Hiddink has never lost an FA Cup match with Chelsea (P5 W5 D0 L0), guiding them to the trophy in 2009.
Manchester City and Chelsea have been drawn together five times in the FA Cup, with the Citizens winning four and losing just one.
In fact, City have won the last four, with the Londoners’ only victory coming back on 20 February 1915.
Manchester City have won six and lost just two of their last 11 matches against Chelsea in all competitions.
Man City have won five and lost just one of the last nine FA Cup matches away from home.
Manchester City have kept a clean sheet in three of their last four competitive away games.
Kelechi Iheanacho has averaged a goal every 70 minutes in all competitions for Manchester City this season (nine goals in 628 mins).