Chelsea have never lost to Southampton under Jose Mourinho but have had their second-ever worst start to a Premier League season.
Radamel Falcao and Loic Remy are vying to start in attack for Chelsea as Diego Costa serves the last of his three-match suspension.
Neither Falcao, Remy nor Oscar travelled to Portugal in midweek for the club’s Champions League tie against Porto, while Nemanja Matic and Eden Hazard started on the bench, but Jose Mourinho is expected to make changes again, with John Terry in contention after sitting out another defeat for the Blues.
Jordy Clasie is in line to make his first Premier League appearance for Southampton after returning to training following an ankle injury, but Ronald Koeman is likely to keep faith with the team that beat Swansea City last weekend, with Ryan Bertrand set to start against his former club after returning in that game.
Kick-off at Stamford Bridge is at 5.30pm.
- Chelsea boss Jose Mourinho has never lost a Premier League game to Southampton (W4 D2).
- Southampton have won just one of their last 13 trips to Stamford Bridge, a 4-2 victory back in January 2002 (D4 L8).
- Both Premier League meetings between these clubs last season ended with a 1-1 scoreline, with all four goals coming in the first half.
- Chelsea have conceded 14 goals this season in their seven Premier League games; just one shy of the total goals conceded by the Blues in their first league season under Mourinho (15 in 38 games in 2004-05).
- Only in 2000-01 did Chelsea have fewer points after seven Premier League games (7) than they have accrued this season (8).
- Ronald Koeman’s side are without a win in 10 Premier League away games (D4 L6), the joint-longest current run on the road in the top-flight (along with Newcastle).
- No side have allowed the opponents more shots on target in the Premier League this season than Chelsea (45), while Southampton have allowed the fewest (17).
- No Premier League side has scored more headed goals this season than Southampton (4 – level with Leicester), while Chelsea have conceded a league-high five goals from headers.
- Sadio Mané has provided three assists this season in his seven Premier League games, as many as he managed in the whole of 2014/15 (30 games).
- Jay Rodriguez has found the back of the net in two of his last three Premier League appearances against Chelsea and in three of his last five appearances against the Blues in all competitions.