Sampson saw on-loan Middlesbrough midfielder Josh Walker dislocate his shoulder in the disappointing 3-1 defeat at home to Hereford on Tuesday night and the youngster has returned to the Riverside amid fears his season could be over.
Striker Steve Guinan is complaining of a hernia problem which may mean he has to miss out while Adebayo Akinfenwa only lasted an hour in midweek and is struggling for fitness.
Midfielder Luke Guttridge missed out against the Bulls after a recurrence of the knee injury which delayed his start to the season. He has been to see a knee specialist and has been rated at 50/50 to make the trip to Whaddon Road.
Centre-half Dean Beckwith may return from hamstring injuries but Abdul Osman (back), Chris McCready (hamstring) and Liam Davis (foot) remain out.
One bright note from Tuesday night was the return of striker Courtney Herbert as a substitute after nine games out with a back injury and the youngster may start if Guinan and Akinfenwa are ruled out.