Spurs will be up against the leading scorer in the FA Cup this season when they tackle Colchester for the first time in their history in their fourth-round tie at the Weston Homes Community Stadium (12.45pm).
Kevin Wimmer will slot in for knee ligament injury victim Jan Vertonghen for Tottenham.
England stars Harry Kane and Dele Alli could start from the bench as Spurs boss Mauricio Pochettino bids to keep his top stars fresh.
Ryan Mason has still failed to recover from his ankle injury.
Former Premier League players Nicky Shorey and Darren Ambrose could earn recalls to Colchester’s starting XI after being named on the bench for the U’s 3-0 defeat at Scunthorpe
Colchester have not won in League One since October, but beat Championship side Charlton in the third round.
This will be the first ever competitive meeting between these sides.
No player has scored more goals in this season’s FA Cup than Colchester’s Macauley Bonne (4).
Tottenham haven’t progressed past this stage since they reached the semi-final in 2012, while Colchester last reached the fifth round in 2006. Both sides were undone by Chelsea in those seasons.
Spurs have lost just one of their last 13 FA Cup games against lower league opposition (W9 D3), though it was their most recent encounter (vs Leeds in the fourth round in 2013).
Spurs are unbeaten in nine successive away matches in all competitions (W6 D3 L0).
The Lilywhites have scored in 14 successive competitive games away from home.
Harry Kane has scored 15 goals in his last 18 appearances for Spurs in all competitions.