Josh Scott will start his first game in over a year when Dagenham host the Saddlers.
The 26-year-old striker missed most of last season having been diagnosed with a blood clot on his lung and then missed further time this year with cartilage damage in his knee.
But he has returned to make a handful of substitute appearances recently and manager John Still has insisted he will start against the Saddlers.
However striker Cristian Montano has not been granted permission to play by parent club West Ham while fellow loanees Exodus Geohaghon and Adam Cunnington have already played in the competition and are cup-tied.
Midfielder Kevin Maher (ankle) could return to the squad after coming through 90 minutes unscathed in a midweek friendly.
The Daggers have several long-term injury absentees with captain Mark Arber (hernia), midfielder Luke Howell (knee) and strike duo Rob Edmans (broken leg) and Sam Williams (knee) still sidelined.
Walsall will be without Mark Wilson for the trip this weekend.
The midfielder only extended his loan spell with the club last Friday but was recalled by parent club Doncaster on Monday due to their injury crisis.
But manager Dean Smith has no new injury or suspension concerns as the Saddlers, struggling in npower League One, aim to progress to the third round.
Teenager Connor Deards could be a surprise inclusion on Walsall’s substitutes’ bench after returning from a loan spell with Redditch United.
The Saddlers will continue to be without defender Darryl Westlake, who has an ankle problem, and midfielder Kevan Hurst is still struggling with a heel injury.