Drogba hurt his back in training on Tuesday and will have a late fitness test ahead of the game.
Defender Alex and Salomon Kalou are both back in the squad after recovering from injury. However, full-back Jose Bosingwa (knee) and Michael Essien (hamstring) remain long-term absentees. Ricardo Carvalho is rested.
Chelsea (from): Cech, Hilario, Turnbull, Ivanovic, Belletti, Alex, Terry, A Cole, Lampard, Ballack, Obi, Malouda, J Cole, Zhirkov, Drogba, Anelka, Kalou, Kakuta, Bruma, Borini.