The Ivory Coast international has recovered from the back injury which kept him out of the side that beat Portsmouth 2-1 at Stamford Bridge on Wednesday night.
Ricardo Carvalho is expected to replace Alex in defence while Joe Cole will come in for Deco. Jose Bosingwa (knee) and Michael Essien (hamstring) are sidelined.
Kick-off is at 4pm.
Chelsea (from): Cech, Hilario, Turnbull, Ivanovic, Belletti, Alex, Carvalho, Terry, A Cole, Lampard, Ballack, Obi, Malouda, J Cole, Zhirkov, Drogba, Anelka, Kalou, Kakuta, Bruma, Borini, Deco, Sturridge, Matic.