The Swans have a habit of upsetting the big guns – becoming only the third team in Premier League history to complete the double over Arsenal and Manchester United in the same season.
And with City slipping up against Burnley, West Ham and Crystal Palace this season, Dyer feels another shock could be on the cards.
“They are a very strong side, but as we’ve seen this season they can be vulnerable,” he told the official Swansea website.
“They’ve lost against lesser teams this season, so we will make sure we do our research to ensure we know what we need to do to stop them and exploit their weaknesses.
“Hopefully we can come away with another three points like we did at Arsenal.”
Eighth-placed Swansea have a chance of qualifying for the Europa League for the second time in three seasons.
And Dyer has hailed the club’s impressive campaign.
“We keep doing something different every year and creating history,” he added.
“We’ve achieved our record points tally and beaten some big teams, so it has been great.
“It’s been a tough season on a personal level. There was a period when I wasn’t playing and people were asking questions over whether I could get back to form.
“But now I’m playing again, and I feel I’m getting back to it. It would be great to finish the season on a high.”
Manuel Pellegrini’s side have a three-point lead over Arsenal in the race for second place but the Gunners have a game in hand.