Police in Lille have used teargas on fans following scuffles in the city centre.
Supporters were seen running through the streets before officers attempted to disperse them by firing the gas into the crowds.
Fans from England, Wales, Slovakia and Russia have been gathering in the city for Group B matches between the countries.
A large group of fans were congregated at the Place des Reignaux when officers used the spray and let off a canister. A loud bang was also heard.
Supporters held their shirts over their mouths and left the scene rubbing their eyes and spitting.
Hoards of fans were seen walking through the streets chanting “England, England, England.”
In footage posted online by ex-England footballer Stan Collymore, one man wearing a green hat is seen smashing wing mirrors off cars parked on the street.
Collymore said: “Somebody threw a, not a grenade, something that went bang towards some England fans and the England fans have just run.”
The bang caused the crowd to surge forward and they dispersed as police fired tear gas.
Around 10 men wearing Russian Ultra t-shirts were seen walking away from the area.
Mounted police quickly arrived on the scene as the England fans regrouped and began to chant again.
In his footage Collymore can be seen pointing to a man who has been pinned down in the road by police and saying: “You were throwing bottles. Yes.”
As quickly as the trouble started it went away and the fans returned to chanting and singing.
Away from the main square a group of England fans, who were comparatively quiet, were surrounded by police as they drank outside Cafe Oz.
Either standing outside or sitting on the grass, the officers parked over ten vans and a police bus in the square around them.