Leeds United won 2-1 at Bolton in their FA Cup fourth-round clash at the Macron Stadium, while Sheffield Wednesday lost 3-2 at League Two side Shrewsbury.
The Shrews stunned their higher-ranked opponents with defender Jack Grimmer’s stoppage time header clinching a 3-2 win over the Owls.
Lewis McGugan had twice put the Championship side ahead but Jean-Louis Akpa Akpro and Shaun Whalley, following up Akpa Akpro’s saved penalty, levelled before Grimmer sent the League One side through to the last 16.
The Championship will still be well represented in the fifth round with Leeds, Blackburn, Hull and Reading all going through.
Leeds won with Souleymane Doukara and new signing Toumani Diagouraga scoring first-half goals at Bolton, with Darren Pratley managing a late reply for the hosts.
Blackburn coasted home 3-0 at League Two Oxford with Ben Marshall scoring twice, one from the penalty spot, and Tony Watt adding another on his debut following his loan move from Charlton.
Oxford had beaten Premier League Swansea in the third round but were 2-0 down by half-time and never looked like producing another upset.
Reading reached the semi-finals last season and might be eyeing another cup run after thrashing League One Walsall 4-0.
Matej Vydra scored twice after Hal Robson-Kanu had opened the scoring and Danny Williams was also on the scoresheet.
On-loan striker Chuba Akpom scored his first senior hat-trick as Championship leaders Hull eased through 3-1 at Bury.
Akpom opened the scoring after 14 minutes and converted his second from the penalty spot close to the hour-mark after Sone Aluko had been tripped.
The Arsenal man completed his treble after 69 minutes for the 2014 finalists, with Craig Jones finding the net late on for the League One Shakers.