Accies could field Darren Lyon after the teenager served a two-match ban, following his red card against Motherwell, but the midfielder also suffered a broken nose at Fir Park and might miss out.
Dougie Imrie is suspended while defender Lucas Tagliapietra (ankle) and young forward Andy Ryan (groin) remain out. Lee Lynch and Jon Routledge left the club during the week.
Hamilton striker Jason Scotland has told his team-mates they all need to take responsibility to rectify their poor goalscoring run as they get set to face the Perth side.
Accies have only scored three goals in 10 games and have not won in 11 matches since manager Alex Neil left for Norwich.
That form has put them in danger of slipping out of the Scottish Premiership top six at the crucial moment, and they will not be able to catch St Johnstone before the split if they lose at home to the Perth side on Saturday.
As well as losing Neil’s influence in midfield, Hamilton saw both of their top goalscorers, Tony Andreu and Mickael Antoine-Curier, depart soon after.
The pair had 21 goals between them and Andreu was top of the Scottish Premiership scoring charts.
Hamilton have only scored in one game since the Frenchman left for Norwich in a £1m deal, with Scotland on target along with Dougie Imrie, who is suspended for the visit of Saints.
Scotland, who has scored three goals in 21 appearances this season, said: “It’s been difficult. We all have to chip in.
“Obviously I take responsibility because I’m a striker and I get paid to score goals but as I tell some of the boys in the dressing room, Tony was a midfielder, not a striker.
“He was leading the league in goalscoring so the midfielders need to chip in as well. Hopefully everyone can contribute and we can start getting some more goals.”
St Johnstone midfielder Simon Lappin has trained all week ahead of the Scottish Premiership clash with Hamilton after recovering from a knee injury.
Frazer Wright and Dave Mackay have also returned to training following injections on niggling injuries.
Steven MacLean could miss out on the artificial surface at New Douglas Park following previous knee operations.