Liverpool captain Jordan Henderson admits the incredible atmosphere at Anfield on Monday night is sure to have players of both sides fired up.
Henderson has plenty of experience of the rivalry in his five years at the club and knows exactly what to expect.
And he admits the biggest problem is not being ready for the game but being in control when it kicks off.
“It is the rivalry, the success both clubs have had and it’s like a derby,” he told LFC TV.
“The atmosphere is incredible and that transcends onto the pitch.
“I don’t think it is one you have to get yourself pumped up for it.
“You can get pumped up for games and sometimes you can cross the line very easily in big games with the adrenaline going.
“You have to make sure you use that in the right way but I am sure it won’t be a problem.”
Matip hails Henderson
Henderson has been utilised in a different position this season after being asked by Klopp to perform the deeper-lying role in midfield.
It is something he has excelled at and that has helped make life easier for his back four.
One of that number Joel Matip, who is set for his first appearance in the fixture, has been impressed with the club captain’s performances.
“He does a very good job. He always has the ball and sometimes I think he is everywhere,” said the centre-back, whose only previous United experience was for Schalke in a 2011 Champions League semi-final 6-1 aggregate defeat.
“That’s always good, especially for the centre-backs like me because you always know he is there and he will help you.
“You can always play (the ball) to him and he gives the team a lot of strength and calm – and sometimes he scores, so perfect.”