Henderson, who spent time on the sidelines with a shoulder problem last season, sustained the injury earlier this summer and is now expected to miss the start of the Sky Bet Championship campaign.
Speaking after Saturday’s 0-0 draw with West Ham, Luzon said: “Stephen Henderson is one of our key players and it looks as if he is going to miss the first month of the season.
“He is going to have to have an operation on his shoulder.
“I am happy with Popey [Nick Pope] and am sure that he will do well for us. It’s the other shoulder to the one he injured last season.”