Vaughan has missed the last two matches and if he returns to contention boss Chris Powell will have a near full-strength squad to choose from.
Winger Harry Bunn and midfielder Jonathan Hogg are hoping to play bigger roles after recovering from respective hamstring and back problems. Both were late substitutes in last week’s home draw against Derby.
Defenders Murray Wallace and David Edgar are also pushing for recalls as Powell’s side bid to extend their unbeaten run to six matches.
Blackburn have huge problems in central defence with four players out injured.
Stand-in skipper Matt Kilgallon (thigh) is expected to join club captain Grant Hanley (calf), Bolton loanee Alex Bapstiste (hamstring) and Shane Duffy (knee) on the sidelines, meaning Darragh Lenihan could make his full debut alongside full-back-cum-centre-half Tommy Spurr.
Boss Gary Bowyer, who also remains without Jason Lowe (foot) and Chris Taylor (groin), has had good news elsewhere, as David Dunn (calf) and Josh King (hamstring) are due back in the squad if they come through Friday’s training session unscathed.
After seeing his strike partner Rudy Gestede pass 20 goals in the midweek win over Millwall, former Terriers striker Jordan Rhodes would also reach that landmark were he to score against his old club.