The England right-back, who left Pompey to move to Anfield in the summer, has been troubled by a hamstring injury and missed Wednesday’s victory over Wigan as a precaution.
Striker Fernando Torres is likely to start having come off the bench to score against the Latics but winger Albert Riera still has a hamstring problem and is not fit.
Forward Ryan Babel returns to the squad after an ankle injury.
Kick-off is at 12.45pm.
Liverpool (from): Reina, Johnson, Carragher, Agger, Insua, Benayoun, Gerrard, Mascherano, Aquilani, Kuyt, Torres, Cavalieri, Lucas, Aurelio, Skrtel, Kyrgiakos, Ngog, Babel, Degen.