Tony Craig returns to the Leyton Orient squad.
The on-loan defender was ineligible for last weekend’s FA Cup exit at the hands of League Two Gillingham as parent club Millwall do not want him cup-tied, and he is set to come straight back in at left-back.
But boss Russell Slade is still without his leading scorer Dean Cox.
The seven-goal winger has been out since suffering a knee injury in mid-November and is expected to be sidelined for at least another fortnight.
Ben Alnwick keeps his place in goal with Jamie Jones and David Button still missing with shoulder injuries, and French striker Jonathan Tehoue is continuing his recovery from a broken wrist.
Striker Daniel Nardiello remains a doubt for Exeter but manager Paul Tisdale is boosted by the return of four other key players.
Nardiello is struggling with a calf injury and will be assessed ahead of kick-off in east London.
Spanish forward Guillem Bauza has shrugged off a hamstring problem to be available for the visit to Orient, while defender Billy Jones is back after a broken toe.
David Noble has recovered from a dead leg in time for the fixture, while midfielders Liam Sercombe and James Dunne are in the frame for a place in Tisdale’s matchday squad following injury.
However, the Grecians boss will have to choose whether to make changes to the team that won 3-0 against Tranmere in Exeter’s last outing a fortnight ago.