Manchester City have had the upper hand over Manchester United recently, but Wayne Rooney will be out to mark his birthday with another derby goal.
Manchester United have no fresh injury problems ahead of the game and could welcome back Ashley Young from a calf injury.
Manchester City, meanwhile, remain without David Silva, Sergio Aguero, Gael Clichy, Samir Nasri and Fabian Delph.
Vincent Kompany is fit again, but City boss Manuel Pellegrini has refused to confirm whether he will return to the starting line-up.
Kick-off at Old Trafford on Sunday is at 2.05pm.
- Manchester City have won six of their last eight Manchester derbies in league competition (L2) – prior to this run City had won six of their previous 42 derby games v Manchester United.
- Manchester City are looking for their 50th competitive win in the Manchester derby (W49 D50 L69).
- None of the last 12 Manchester derbies in all competitions have ended as a draw (five United wins, seven City wins).
- The last 10 Manchester derbies in all competitions have seen 41 goals scored (4.1 goals per game).
- Wayne Rooney has scored 11 goals in Manchester derbies (all competitions), more than any other player in this fixture.
- Rooney turned 30 on Friday – no player has scored as many Premier League goals as he has by the age of 30 (187).
- Manchester United have won 17 of their 23 Premier League home games under Louis van Gaal (74%), conceding just 16 goals (D3 L3).
- Manchester City have had the most shots on target (74) and have allowed their opponents the fewest (24) in the opening nine matchdays of 2015-16.
- Kevin De Bruyne has 23 assists in 41 league appearances since the start of last season, three more than any other player in the top five European Leagues.
- Manchester City will be missing Sergio Aguero for this game – he’s scored eight goals in eight Manchester derbies in all competitions, including all three for City v Utd last season.