Moxey received two yellow cards during the home defeat on Boxing Day and must serve a one-match ban.
There are further problems in defence for the Rams after on-loan right-back Fredrik Stoor returned to Fulham. The Sweden international’s stay at Pride Park expired following the 2-0 loss to the Seasiders.
Nigel Clough will hope either Shaun Barker (thigh), Miles Addison (foot) or Dean Leacock (knee) will be fit enough to return to the side.
Paul Green could come back into the reckoning after a bout of flu while fellow midfielder Jake Livermore will play the final game of his loan spell before returning to Tottenham.
Kick-off at St James’ Park is at 5.20pm.