Murphy missed the Iron’s last game – a 1-1 draw at Reading – through suspension, and he will replace Josh Lillis between the sticks.
Scunthorpe’s scheduled clash with Ipswich was postponed last Saturday and the cancellation has allowed club captain Cliff Byrne (hamstring) and winger Martyn Woolford (foot) to improve their fitness levels.
Kenny Milne is still out, though. The Scottish defender has yet to make an appearance for United after joining 18 months ago because of a knee injury. He has recently returned from a spell of treatment in America.
Striker Ben May (ankle) is also a long-term absentee.