Oxford look set to be without Patrick Hoban when they host former boss Chris Wilder and his Northampton side.
The striker is rated as 50/50 to feature having suffered a dead leg in the 0-0 draw at AFC Wimbledon which forced him off in the 32nd minute.
Head coach Michael Appleton has also revealed that Andy Whing, who made his first start since December, is carrying a knock along with George Baldock.
Appleton also confirmed that Jamie Ashdown will start once more. The former Portsmouth goalkeeper has been given the final games of the season to stake his claim for a new contract at the Kassam.
Northampton may not risk 17-goal striker Marc Richards after his recovery from an Achilles injury.
Richards could make the bench but boss Wilder may look to keep him for Saturday’s game with Cheltenham.
Ryan Cresswell and Jason Taylor are out as the pair serve two-game bans for the Cobblers.
Ricky Holmes will be assessed after the midfielder missed Saturday’s 2-1 defeat to Stevenage which put a major dent in the Cobblers’ slim play-off hopes.
Breaking news, transfer gossip, line ups and goal alerts from your football club – delivered direct to your mobile. Sign up for Sky Sports Alerts