The teams will meet at Cardiff City Stadium on Friday locked at the top of Group B on 11 points after recording a goalless draw in their first encounter in Brussels in November.
Wales have the chance to win their group and make their first appearance at the European Championships.
Should they beat Belgium, Arsenal midfielder Ramsey believes it will be Wales’ biggest victory since the 2-1 win over Italy in 2002 during their Euro 2004 qualifying campaign.
“I wasn’t involved then but it’s the biggest game Wales have been involved in since then,” Ramsey said.
“It’s probably the biggest game we’ve played in playing for Wales with this group of players. We are both top of the league at the moment and there’s a lot on this game.
“We have started off fantastically and hopefully we can get a result there to put us in a really good position.
“We don’t fear them, I don’t fear any team I go up against. It’s about concentrating on my own personal performance and the team’s performance and seeing where that takes us.
“If this group are all switched on together, we’ll give anyone a game. We’re at that stage in our development where we can take on teams like this.”
Gareth Bale will boost Welsh hopes of a win at home and Ramsey is keen to link up with the Real Madrid star.
“Our understanding is really good, he is a top quality player and it’s always nice to play with those sort of players,” said the 24-year-old.
“The group we have at the moment is probably the best group we have had.
“I think everybody in the whole team has had to raise their game and bring that togetherness to make us more of a stronger unit.
“That’s what this team has been built on. You can see everyone is out there fighting for each other and working their socks off and we have a lot of quality as well when we go forward so we’re dangerous.”
Ramsey linked up with the squad having helped Arsenal defend the FA Cup with a 4-0 final win over Aston Villa last month.