Wojciech Szczesny is set to be back in goal, while the likes of England duo Theo Walcott and Danny Welbeck are also pressing for a start.
France defender Mathieu Debuchy may also be included in the squad again, having been out since January after needing shoulder surgery. However, captain Mikel Arteta (ankle) and midfielder Alex Oxlade-Chamberlain (groin) are still not match fit.
Pavel Pogrebnyak will be available for Reading having overcome a calf complaint.
The Russia international missed Tuesday’s 1-0 loss to Bournemouth but has been given the green light to feature at Wembley, where Jem Karacan will captain the side should he start a third straight game after long-term injury.
Nathan Ake and Kwesi Appiah, on loan from Chelsea and Crystal Palace respectively, are cup-tied for the semi-final, but fellow loanees Nathaniel Chalobah and Jamie Mackie are available