Conor McLaughlin is likely to make his home debut for Shrewsbury, with Joe Jacobson still a doubt.
Versatile full-back McLaughlin arrived on loan from Preston until the end of the season and made his bow 24 hours later in Saturday’s 1-1 draw at Crewe.
He was brought in as Jacobson continues to struggle with a groin strain which had threatened his eventual involvement in last Monday’s 2-1 victory over Crawley.
Jermaine Grandison was also recalled to defence at Gresty Road while Marvin Morgan started up front, with Shane Cansdell-Sherriff and Terry Gornell dropping to the bench.
Manager Graham Turner is not expected to have any new injury concerns and could opt to keep faith with an unchanged XI, although the likes of Gornell, Nicky Wroe, Romaine Sawyers and Lionel Ainsworth are all on hand should he wish to freshen up his ranks.
“This is a massive week,” said Turner, ahead of the visits of Oxford and Burton. “We’ve got a great record at home, we’ve got to go on with that record between now and the end of the season.”
Meanwhile, Oxford manager Chris Wilder will have to contend with James Constable’s suspension in addition to an injury nightmare.
Striker Constable was sent off after just 11 minutes of the U’s’ derby clash with Swindon on Saturday for elbowing Robins centre-back Joe Devera, and starts a three-match ban at the Greenhous Meadow.
Meanwhile, Wilder will be without six other senior professionals against the Shrews.
Midfielder Peter Leven has been ruled out of the contest with a shoulder injury, while captain Jake Wright is unlikely to play a part because of a back problem.
Tom Craddock is still recovering from a knee complaint and fellow striker Jon-Paul Pittman will remain on the sidelines after aggravating a hamstring injury.
Winger Alfie Potter is out for the season after breaking his ankle in training and defender Tony Capaldi has yet to make his debut for the U’s after joining from Morecambe in the summer because of a succession of injuries.