Manchester United head to Southampton with the unenviable record of not keeping a clean sheet in any of their last seven league games against Saints.
Wayne Rooney is fit, but left-back Luke Shaw may not play again this season after his horrific double leg break against PSV Eindhoven, so Daley Blind is set to replace him with Marcos Rojo set to earn his first league start of this campaign at centre-back.
Marouane Fellaini returns after illness.
Southampton forward Sadio Mane could be restored to the starting line-up after being on the bench last weekend.
Ryan Bertrand, Jordy Clasie, Fraser Forster and Florin Gardos are all sidelined and Gaston Ramirez is a doubt.
Kick-off at St Mary’s Stadium on Sunday is at 4pm.
- Manchester United have not kept a clean sheet in any of their last seven league games against Southampton.
- When Southampton have conceded first against Manchester United in the Premier League they have go on to lose all but one of those matches (D1 L15).
- All four of the league meetings between Ronald Koeman and Louis van Gaal have ended as away wins (2006-07 PSV v AZ in Eredivisie and 2014-15 Southampton v Man Utd).
- Ronald Koeman replaced Louis van Gaal as manager of AZ in 2009 after the latter moved to Bayern Munich, but was replaced himself after losing seven of his first 16 games in charge.
- There has been just one red card in the 32 Premier League meetings between Saints and Man Utd; that came in the 6-3 victory for the Saints in October 1996.
- Southampton have been solid at home; winning five and losing just one of their last seven PL games at St Mary’s Stadium.
- However, Southampton have won just two of their last 11 Premier League matches (W2 D4 L5).
- Manchester United have won just seven of their 21 Premier League away matches under Louis van Gaal (W7 D8 L6).
- Manchester United scored with all three of their shots on target against Liverpool.
- The Red Devils have covered more ground than any other Premier League side after five matchdays (578.5km).