It is understood Spurs have agreed a deal with the newly-relegated Clarets, with the usual formalities of a medical and the final agreement of personal terms all that is left to conclude.
Tottenham are one of a number of clubs interested in the defender, who impressed in the Premier League last season despite Burnley’s relegation, including newly-promoted Bournemouth.
Both clubs are refusing to comment but Trippier is set to become Spurs’ second signing of the season after the Austria defender Kevin Wimmer completed his move last month, and will provide competition to Kyle Walker for a place at right-back.
Trippier joined Burnley from Manchester City in 2012 after an impressive loan spell followed two previous, temporary stints at Barnsley.
He never made a first team appearance for City but has played over 150 times for Burnley and scored four goals.
Trippier has also represented every England team from U18 to U21 level but is yet to be called up to the England senior team.
Spurs are keen to strengthen themselves defensively this summer and also have an interest in the Barcelona centre-back Marc Bartra.