Danny Grainger could be available for St Johnstone.
Grainger missed the win over Aberdeen at the weekend with a groin injury but will be assessed on Monday.
Midfielder Murray Davidson was taken off against the Dons with a hip injury and is a doubt.
Midfielder Jon Routledge could feature for Hamilton after returning to training following a knee injury.
Skipper Alex Neil is definitely back after serving a one-match suspension during Saturday’s win over Hibernian.
Defender Martin Canning remains on the sidelines with a stomach injury.
St Johnstone (from): Enckelman, MacKay, Anderson, Duberry, Grainger, Adams, Millar, Davidson, Maybury, Moon, Craig, Jackson, Reynolds, MacDonald, May, Smith, Durnan, Invincibile, Robertson.
Hamilton (from): Cerny, McLaughlin, Buchanan, Elliott, McDonald, McAlister, Neil, Carrington, Antoine-Curier, Crawford, Mensing, Imrie, Hasselbaink, Chambers, Murdoch, Routledge, Kilday, Gillespie.