Tottenham trio Mousa Dembele, Kyle Walker and Danny Rose will all be rested against Qarabag ahead of the clash with Chelsea on Sunday.
Manager Mauricio Pochettino has criticised Spurs’ schedule as they face a trip to the Azerbaijani side in the Europa League only three days before their midday kick-off against their London rivals.
And the Argentinian has opted to leave three players likely to start against Chelsea at home, although star striker Harry Kane is part of the squad which travels to Azerbaijan.
“Nabil [Bentaleb] is still out, he got a bad tackle during international duty with Algeria and he is out now,” Pochettino said.
“Alex Pritchard, Nacer Chadli and Erik Lamela are also out and we have rested a few players for this game as well.
“It has been a very busy period and we need all the squad ready to compete in good condition. We need to assess all of the players after every game and make sure we make the best decisions to compete with all of the players in the best condition.”
With numerous changes likely to be made, summer signing Kieran Trippier and former Swansea left-back Ben Davies are expected to be handed starts.
Meanwhile, youngsters Josh Onomah, Harry Winks and goalkeeper Luke McGee could all feature after travelling with the squad, and Pochettino is delighted at the club’s success at bringing players through the academy.
“It is great for the club to be able to give the possibility for young players to play with us and travel with the first team,” he added.
“I think it is fantastic and this is the future of the club. We feel proud about that and it is a very important thing for the club.”