Tottenham manager Harry Redknapp says Gareth Bale is “very doubtful” to play due to an ankle injury.
Aaron Lennon is out with a hamstring injury, Ledley King’s chronic knee injury means he is unlikely to step out against the Blues after playing against Sunderland at the weekend, and Jermain Defoe is a doubt due to a hamstring problem.
Younes Kaboul returns from suspension, Emmanuel Adebayor has a minor foot injury but should play, while long-term absentees Tom Huddlestone (ankle) and Michael Dawson (Achilles) remain sidelined.
John Terry has shaken off the Achilles tweak he suffered during open training on Monday and will lead out the Chelsea side at White Hart Lane.
Midfielder Ramires has recovered from a leg injury but defender David Luiz is still out with a knee problem, joining long-term injury victim Michael Essien on the sidelines.
Tottenham (from): Gomes, Friedel, Cudicini, Bale, Corluka, Bassong, Rose, Kaboul, Gallas, King, Walker, Assou-Ekotto, Parker, Modric, Livermore, Townsend, Carroll, Fredericks, Falque, Sandro, Pienaar, Pavlyuchenko, Defoe, Dos Santos, Adebayor, Van der Vaart, Kane.
Chelsea (from): Cech, Bosingwa, Ivanovic, Terry, Cole, Mikel, Romeu, Lampard, Ramires, McEachran, Mata, Malouda, Meireles, Torres, Drogba, Kalou, Sturridge, Lukaku, Turnbull.