Waddock saw his side slip to a disappointing 4-0 defeat at Yeovil on Boxing Day which left the Chairboys six points adrift of safety and he will make alterations for the clash with Gus Poyet’s side.
Brighton drew 0-0 with Leyton Orient on Boxing Day and remain in the relegation zone themselves, just three points ahead of Wanderers.
Midfielder Kadeem Harris could again be involved after the 16-year-old became the club’s youngest ever player in the Football League as a substitute against the Glovers.
On-loan Bristol City forward John Akinde serves the second of a three-game ban after his recent red card against Oldham while midfielder Lewis Montrose (knee) and defender Leon Johnson (hip) remain sidelined.
Waddock admitted his side had been outplayed in the crucial areas against Yeovil.
Kieran Murtagh opened the scoring in the first half and the Glovers ran riot in the final quarter of the game with goals from JP Kalala, Jon Obika and Sam Williams.
Yeovil goalkeeper Alex McCarthy also made a big impression with some fantastic saves.
Waddock said: “The difference between the teams was in the two boxes. They have a very talented young keeper and he made some great saves.
“But we were not without fault at the back and they punished us for our mistakes.
“It is results that count and whatever way you dress it up we got beat 4-0.”